Direct Construction of Recursive MDS Diffusion Layers using Shortened BCH Codes

MDS matrices allow to build optimal linear diffusion layers in block ciphers. However, MDS matrices cannot be sparse and usually have a large description, inducing costly software/hardware implementations. Recursive MDS matrices allow to solve this problem by focusing on MDS matrices that can be computed as a power of a simple companion matrix, thus having a compact description suitable even for constrained environ- ments. However, up to now, finding recursive MDS matrices required to perform an exhaustive search on families of companion matrices, thus limiting the size of MDS matrices one could look for. In this article we propose a new direct construction based on shortened BCH codes, al- lowing to efficiently construct such matrices for whatever parameters. Unfortunately, not all recursive MDS matrices can be obtained from BCH codes, and our algorithm is not always guaranteed to find the best matrices for a given set of parameters.Comment: Best paper award; Carlos Cid and Christian Rechberger. 21st International Workshop on Fast Software Encryption, FSE 2014, Mar 2014, London, United Kingdom. springe

Recursive Diffusion Layers for Block Ciphers and Hash Functions

Many modern block ciphers use maximum distance separable (MDS) matrices as the main part of their diffusion layers. In this paper, we propose a new class of diffusion layers constructed from several rounds of Feistel-like structures whose round functions are linear. We investigate the requirements of the underlying linear functions to achieve the maximal branch number for the proposed 4*4 words diffusion layer. The proposed diffusion layers only require word-level XORs, rotations, and they have simple inverses. They can be replaced in the diffusion layer of the block ciphers MMB and Hierocrypt to increase their security and performance, respectively. Finally, we try to extend our results for up to 8*8 words diffusion layers

Using MILP in Analysis of Feistel Structures and Improving Type II GFS by Switching Mechanism

Some features of Feistel structures have caused them to be considered as an efficient structure for design of block ciphers. Although several structures are proposed relied on Feistel structure, the type-II generalized Feistel structures (GFS) based on SP-functions are more prominent. Because of difference cancellation, which occurs in Feistel structures, their resistance against differential and linear attack is not as expected. Hitherto, to improve the immunity of Feistel structures against differential and linear attack, two methods are proposed. One of them is using multiple MDS matrices, and the other is using changing permutations of sub-blocks. In this paper by using MILP and summation representation method, a technique to count the active S-boxes is proposed. Moreover in some cases, the results proposed by Shibutani at SAC 2010 are improved. Also multiple MDS matrices are applied to GFS, and by relying on a new proposed approach, the new inequalities related to using multiple MDS matrices are extracted, and results of using the multiple MDS matrices in type II GFS are evaluated. Finally results related to linear cryptanalysis are presented. Our results show that using multiple MDS matrices leads to 22% and 19% improvement in differential cryptanalysis of standard and improved 8 sub-blocks structures, respectively, after 18 rounds

Comparison of Effects of Ivabradine versus Carvedilol in Murine Model with the Coxsackievirus B3-Induced Viral Myocarditis

BACKGROUND: Elevated heart rate is associated with increased cardiovascular morbidity. The selective I(f) current inhibitor ivabradine reduces heart rate without affecting cardiac contractility, and has been shown to be cardioprotective in the failing heart. Ivabradine also exerts some of its beneficial effects by decreasing cardiac proinflammatory cytokines and inhibiting peroxidants and collagen accumulation in atherosclerosis or congestive heart failure. However, the effects of ivabradine in the setting of acute viral myocarditis and on the cytokines, oxidative stress and cardiomyocyte apoptosis have not been investigated. METHODOLOGY/PRINCIPAL FINDINGS: The study was designed to compare the effects of ivabradine and carvedilol in acute viral myocarditis. In a coxsackievirus B3 murine myocarditis model (Balb/c), effects of ivabradine and carvedilol (a nonselective β-adrenoceptor antagonist) on myocardial histopathological changes, cardiac function, plasma noradrenaline, cytokine levels, cardiomyocyte apoptosis, malondialdehyde and superoxide dismutase contents were studied. Both ivabradine and carvedilol similarly and significantly reduced heart rate, attenuated myocardial lesions and improved the impairment of left ventricular function. In addition, ivabradine treatment as well as carvedilol treatment showed significant effects on altered myocardial cytokines with a decrease in the amount of plasma noradrenaline. The increased myocardial MCP-1, IL-6, and TNF-α. in the infected mice was significantly attenuated in the ivabradine treatment group. Only carvedilol had significant anti-oxidative and anti-apoptoic effects in coxsackievirus B3-infected mice. CONCLUSIONS/SIGNIFICANCE: These results show that the protective effects of heart rate reduction with ivabradine and carvedilol observed in the acute phase of coxsackievirus B3 murine myocarditis may be due not only to the heart rate reduction itself but also to the downregulation of inflammatory cytokines

Out of Oddity – New Cryptanalytic Techniques Against Symmetric Primitives Optimized for Integrity Proof Systems

International audienceThe security and performance of many integrity proof systems like SNARKs, STARKs and Bulletproofs highly depend on the underlying hash function. For this reason several new proposals have recently been developed. These primitives obviously require an in-depth security evaluation, especially since their implementation constraints have led to less standard design approaches. This work compares the security levels offered by two recent families of such primitives, namely GMiMC and HadesMiMC. We exhibit low-complexity distinguishers against the GMiMC and HadesMiMC permutations for most parameters proposed in recently launched public challenges for STARK-friendly hash functions. In the more concrete setting of the sponge construction corresponding to the practical use in the ZK-STARK protocol, we present a practical collision attack on a round-reduced version of GMiMC and a preimage attack on some instances of HadesMiMC. To achieve those results, we adapt and generalize several cryptographic techniques to fields of odd characteristic

Cardiovascular disease, risk factors and heart rate variability in the elderly general population: Design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study

BACKGROUND: The increasing burden of cardiovascular diseases (CVD) in the ageing population of industrialized nations requires an intensive search for means of reducing this epidemic. In order to improve prevention, detection, therapy and prognosis of cardiovascular diseases on the population level in Eastern Germany, it is necessary to examine reasons for the East-West gradient of CVD morbidity and mortality, potential causal mechanisms and prognostic factors in the elderly. Psychosocial and nutritional factors have previously been discussed as possible causes for the unexplained part of the East-West gradient. A reduced heart rate variability appears to be associated with cardiovascular disease as well as with psychosocial and other cardiovascular risk factors and decreases with age. Nevertheless, there is a lack of population-based data to examine the role of heart rate variability and its interaction with psychosocial and nutritional factors regarding the effect on cardiovascular disease in the ageing population. There also is a paucity of epidemiological data describing the health situation in Eastern Germany. Therefore, we conduct a population-based study to examine the distribution of CVD, heart rate variability and CVD risk factors and their associations in an elderly East German population. This paper describes the design and objectives of the CARLA Study. METHODS/DESIGN: For this study, a random sample of 45–80 year-old inhabitants of the city of Halle (Saale) in Eastern Germany was drawn from the population registry. By the end of the baseline examination (2002–2005), 1750 study participants will have been examined. A multi-step recruitment strategy aims at achieving a 70 % response rate. Detailed information is collected on own and family medical history, socioeconomic, psychosocial, behavioural and biomedical factors. Medical examinations include anthropometric measures, blood pressure of arm and ankle, a 10-second and a 20-minute electrocardiogram, a general physical examination, an echocardiogram, and laboratory analyses of venous blood samples. On 200 participants, a 24-hour electrocardiogram is recorded. A detailed system of quality control ensures high data quality. A follow-up examination is planned. DISCUSSION: This study will help to elucidate pathways to CVD involving autonomic dysfunction and lifestyle factors which might be responsible for the CVD epidemic in some populations

Sympathetic Activation and Baroreflex Function during Intradialytic Hypertensive Episodes

BACKGROUND: The mechanisms of intradialytic increases in blood pressure are not well defined. The present study was undertaken to assess the role of autonomic nervous system activation during intradialytic hypertensive episodes. METHODOLOGY/PRINCIPAL FINDINGS: Continuous interbeat intervals (IBI) and systolic blood pressure (SBP) were monitored during hemodialysis in 108 chronic patients. Intradialytic hypertensive episodes defined as a period of at least 10 mmHg increase in SBP between the beginning and the end of a dialysis session or hypertension resistant to ultrafiltration occurring during or immediately after the dialysis procedure, were detected in 62 out of 113 hemodialysis sessions. SBP variability, IBI variability and baroreceptor sensitivity (BRS) in the low (LF) and high (HF) frequency ranges were assessed using the complex demodulation technique (CDM). Intradialytic hypertensive episodes were associated with an increased (n = 45) or decreased (n = 17) heart rate. The maximal blood pressure was similar in both groups. In patients with increased heart rate the increase in blood pressure was associated with marked increases in SBP and IBI variability, with suppressed BRS indices and enhanced sympatho-vagal balance. In contrast, in those with decreased heart rate, there were no significant changes in the above parameters. End-of-dialysis blood pressure in all sessions associated with hypertensive episode was significantly higher than in those without such episodes. In logistic regression analysis, predialysis BRS in the low frequency range was found to be the main predictor of intradialytic hypertension. CONCLUSION/SIGNIFICANCE: Our data point to sympathetic overactivity with feed-forward blood pressure enhancement as an important mechanism of intradialytic hypertension in a significant proportion of patients. The triggers of increased sympathetic activity during hemodialysis remain to be determined. Intradialytic hypertensive episodes are associated with higher end-of-dialysis blood pressure, suggesting that intradialytic hypertension may play a role in generation of interdialytic hypertension

Cardiovascular health and particulate vehicular emissions: a critical evaluation of the evidence

A major public health goal is to determine linkages between specific pollution sources and adverse health outcomes. This paper provides an integrative evaluation of the database examining effects of vehicular emissions, such as black carbon (BC), carbonaceous gasses, and ultrafine PM, on cardiovascular (CV) morbidity and mortality. Less than a decade ago, few epidemiological studies had examined effects of traffic emissions specifically on these health endpoints. In 2002, the first of many studies emerged finding significantly higher risks of CV morbidity and mortality for people living in close proximity to major roadways, vs. those living further away. Abundant epidemiological studies now link exposure to vehicular emissions, characterized in many different ways, with CV health endpoints such as cardiopulmonary and ischemic heart disease and circulatory-disease-associated mortality; incidence of coronary artery disease; acute myocardial infarction; survival after heart failure; emergency CV hospital admissions; and markers of atherosclerosis. We identify numerous in vitro, in vivo, and human panel studies elucidating mechanisms which could explain many of these cardiovascular morbidity and mortality associations. These include: oxidative stress, inflammation, lipoperoxidation and atherosclerosis, change in heart rate variability (HRV), arrhythmias, ST-segment depression, and changes in vascular function (such as brachial arterial caliber and blood pressure). Panel studies with accurate exposure information, examining effects of ambient components of vehicular emissions on susceptible human subjects, appear to confirm these mechanisms. Together, this body of evidence supports biological mechanisms which can explain the various CV epidemiological findings. Based upon these studies, the research base suggests that vehicular emissions are a major environmental cause of cardiovascular mortality and morbidity in the United States. As a means to reduce the public health consequences of such emissions, it may be desirable to promulgate a black carbon (BC) PM2.5 standard under the National Ambient Air Quality Standards, which would apply to both on and off-road diesels. Two specific critical research needs are identified. One is to continue research on health effects of vehicular emissions, gaseous as well as particulate. The second is to utilize identical or nearly identical research designs in studies using accurate exposure metrics to determine whether other major PM pollutant sources and types may also underlie the specific health effects found in this evaluation for vehicular emissions